An SEDL Translator

Modification of a Specific Class of Plasmodesmata and Loss of Sucrose Export Ability in the sucrose export defectivel Maize Mutant

We report on the export capability and structural and ultrastructural characteristics of leaves of the sucrose export defectivel (sedl; formerly called sulí) maize mutant. Whole-leaf autoradiography was combined with light and transmission electron microscopy to correlate leaf structure with differences in export capacity in both wild-type and sedl plants. Tips of sedl blades had abnormal accum...

Crystallization and preliminary X-ray crystallographic analysis of SEDL.

SEDL (known also as sedlin) is a 140 amino-acid protein with a putative role in endoplasmic reticulum-to-Golgi transport. Several missense mutations and deletion mutations in the SEDL gene, which result in protein truncation by frame shift, are responsible for spondyloepiphyseal dysplasia tarda, a progressive skeletal disorder. The protein is identical to MIP-2A, which was shown to interact phy...

A novel nonsense mutation in the sedlin gene (SEDL) causes severe spondyloepiphyseal dysplasia tarda in a five-generation Chinese pedigree.

Spondyloepiphyseal dysplasia tarda (SEDT) is an X-linked recessive osteochondrodysplasia characterized by disproportionately short stature and degenerative joint disease. The objective of this study was to describe a novel nonsense mutation in the sedlin gene (SEDL) causing severe SEDT in a large Chinese pedigree. The clinical features of all affected individuals and female carriers were presen...

SEDL Letter: Putting Reading First

A Rare Presentation of Idiopathic Spinal Epidural Lipomatosis

*Associate Professor, ** Professor and Head, ***Resident, Institution Department of Radiodiagnosis, S. N. Medical College, Agra, U.P., India. Abstract Spinal epidural lipomatosis (SEDL) is defined as pathological overgrowth of the normal extra-dural fat and often causes dural impingement, commonly involving lumbar and thoracic spine. It is most often associated with exogenous steroid therapy an...